Preparation of pancreatic fragments for studying the role of nerves and islets on pancreatic exocrine secretion
نویسنده
چکیده
Pancreatic exocrine secretion is under neurohormonal regulation (1) (Figure 1). In order to completely assess the effects of bioactive agents on acinar cell secretion, it is imperative that the in vitro preparation employed should contain not only acinar cells, but also nerves and islets. Pancreatic lobules / fragments represent such a preparation. Nerve and islet function can be individually blocked by pharmacological agents to permit an appreciation of the indirect effects of the bioactive agent being studied on acinar cell secretion.
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